Blar i forfatter "Zhou, Huimin"

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    • Comprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs 

      Cheng, Lei; Gao, Shuhang; Song, Xiaobo; Dong, Weijie; Zhou, Huimin; Zhao, Lifen; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Glycosylation has significant effects on cancer progression. Fucosylation is one of the most important glycosylation events involved in hepatocellular carcinoma (HCC). Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating ...

    • Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo 

      Liu, Yinhui; Song, Xiaobo; Zhou, Huimin; Zhou, Xue; Xia, Yunlong; Dong, Xin; Zhong, Wei; Tang, Shaoying; Wang, Lili; Wen, Shu; Xiao, Jing; Tang, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      Background: Statin has been widely used to treat hyperlipidemia because of its high potency in decreasing cholesterol levels. The present study aimed to examine the lipid-lowering effect of rosuvastatin and the composition, diversity and species abundance of gut microbiome in association with rosuvastatin efficacy. <br> <br> TRIAL REGISTRATION: ChiCTR-ORC-17013212 at the First Affiliated Hospital ...

    • Reversal effect of ST6GAL 1 on multidrug resistance in human leukemia by regulating the PI3K/Akt pathway and the expression of P-gp and MRP1 

      Ma, Hongye; Cheng, Lei; Hao, Keji; Li, Yanping; Song, Xiaobo; Zhou, Huimin; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia 

      Zhao, Lifen; Li, Yan; Song, Xiaobo; Zhou, Huimin; Li, Nana; Miao, Yuan; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Chemotherapy resistance frequently drives tumor progression. Increased expression of ST8SIA4 has been reported in diverse carcinomas and highly correlates with leukemia multidrug resistance (MDR). MicroRNAs (miRNA) are widely recognized as key players in cancer progression and drug resistance. Here, to explore whether miRNA modulates the sensitivity of chronic myelocytic leukemia (CML) to chemotherapeutic ...